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Viomellein

CAT: 0804-HY-123888Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123888Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Viomellein is a SUMOylation inhibitor with antibacterial and anticancer activities. Viomellein inhibits biofilm formation of strains produced from the fungus Aspergillus ochraceus from the Mediterranean sponge Agelas oroides. Viomellein exhibits cytotoxicity against A2780 human ovarian cancer cells with an IC50 value of 5.0 μM. Viomellein also inhibits SUMOylation of RanGAP1 (GTPase activating protein) with an IC50 of 10.2 μM[1][2][3].
CAS Number
55625-78-0
UNSPSC
12352005
Target
Bacterial; E1/E2/E3 Enzyme
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/viomellein.html
Smiles
O=C1C2=C(O)C3=C(C(C(OC)=C(C4=C(OC)C=C5C=C(C[C@@H](C)O6)C(C6=O)=C(O)C5=C4O)C3=O)=O)C=C2C[C@@H](C)O1
Molecular Formula
C30H24O11
Molecular Weight
560.50
References & Citations
[1]Cryptic Secondary Metabolites from the Sponge-Associated Fungus Aspergillus ochraceus|[2]Kumla D, et al. 1,3-Dioxepine and spiropyran derivatives of viomellein and other dimeric naphthopyranones from cultures of Aspergillus elegans KUFA0015 and their antibacterial activity. Phytochemistry. 2021 Jan;181:112575|[3]Hirohama M, et al. Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2. ACS Chem Biol. 2013 Dec 20;8 (12) :2635-42.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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