Citicoline

• Description:

  Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline inhibits reactive oxygen species (ROS) and apoptosis. Citicoline can be used for neurological disease and hearing loss study[1][2][3].

• Product Name Alternative:

  Cytidine diphosphate-choline; CDP-Choline; Cytidine 5'-diphosphocholine

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Caspase; Endogenous Metabolite; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Citicoline.html

• Purity:

  99.59

• Solubility:

  DMSO : < 1 mg/mL|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  NC(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OCC[N+](C)(C)C)([O-])=O)(O)=O)O2)=NC1=O

• Molecular Formula:

  C14H26N4O11P2

• Molecular Weight:

  488.32

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703.|[2]Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158 (3) :315-7.|[3]Zhong Z, et al. Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage. Front Cell Dev Biol. 2020 Aug 31;8:712.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Caspase 3; Caspase 8; Caspase 9; Human Endogenous Metabolite; Microbial Metabolite

• Citation 01:

  BioRxiv. 2025 April 09.|Nat Neurosci. 2023 Apr;26 (4) :542-554.|Patent. US20240269160A1.|Int J Biol Macromol. 2025 Jan 5:139536.

• CAS Number:

  [987-78-0]