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Citicoline

CAT: 0804-HY-B0739-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0739-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline inhibits reactive oxygen species (ROS) and apoptosis. Citicoline can be used for neurological disease and hearing loss study[1][2][3].
CAS Number
987-78-0
Product Name Alternative
Cytidine diphosphate-choline; CDP-Choline; Cytidine 5'-diphosphocholine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Caspase; Endogenous Metabolite; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Citicoline.html
Purity
99.59
Solubility
DMSO : < 1 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
NC(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OCC[N+](C)(C)C)([O-])=O)(O)=O)O2)=NC1=O
Molecular Formula
C14H26N4O11P2
Molecular Weight
488.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703.|[2]Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158 (3) :315-7.|[3]Zhong Z, et al. Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage. Front Cell Dev Biol. 2020 Aug 31;8:712.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Caspase 3; Caspase 8; Caspase 9; Human Endogenous Metabolite; Microbial Metabolite
Citation 01
BioRxiv. 2025 April 09.|Nat Neurosci. 2023 Apr;26 (4) :542-554.|Patent. US20240269160A1.|Int J Biol Macromol. 2025 Jan 5:139536.

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