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CGS25155

CAT: 0804-HY-105351Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-105351Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGS25155 is an orally active neutral endopeptidase 24.11 (NEP 24.11) inhibitor with an IC50 of 3 nM. CGS25155 can slow down the degradation of the cardiac hormone atrial natriuretic peptide (ANP) and exhibits antihypertensive activity in the DOCA-salt induced rat hypertension model. CGS25155 can be used in cardiovascular disease research[1].
CAS Number
150126-87-7
UNSPSC
12352005
Target
Neprilysin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cgs25155.html
Smiles
O=C([C@H]1NC([C@@H](CCCCCC1)CSC(C)=O)=O)N2[C@@H](C[C@H](C2)O)C(OCC3=CC=CC=C3)=O
Molecular Formula
C25H34N2O6S
Molecular Weight
490.61
References & Citations
[1]MacPherson LJ, et al. Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor. J Med Chem. 1993 Nov 26;36 (24) :3821-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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