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CD4, Human (HEK293, His)

CAT: 0804-HY-P70537-01Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P70537-01Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD4 Protein is an integrated membrane glycoprotein that plays various roles in immune responses and defending against internal and external attacks. The alpha-helix structure of CD4 Protein and HIV-1 Vpu can be involved in the binding and degradation of CD4 molecules. CD4 Protein participates in the differentiation/activation, cytokine expression, and cell migration in macrophages or NK cells through a TCR/LCK-independent pathway. CD4 Protein can enhance the host's immune response to viral infections and boost anti-tumor immunity. CD4 Protein, Human (HEK293, His) is a recombinant CD4 protein with a His tag, expressed in HEK293.
Product Name Alternative
CD4 Protein, Human (HEK293, His), Human, HEK293
UNSPSC
12352202
Type
Recombinant Proteins
Assay Protocol
https://www.medchemexpress.com/cytokines/scd4-protein-human-hek-293-his.html
Purity
95.0
Smiles
KKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTW
Molecular Formula
920 (Gene_ID) P01730 (K26-W390) (Accession)
Molecular Weight
49-58 kDa
References & Citations
[1]Tiganos E, et al. Putative alpha-helical structures in the human immunodeficiency virus type 1 Vpu protein and CD4 are involved in binding and degradation of the CD4 molecule. J Virol. 1997 Jun;71 (6) :4452-60.|[2]Bernstein HB, et al. CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration. J Immunol. 2006 Sep 15;177 (6) :3669-76. |[3]Zhen A, et al. CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J Virol. 2014 Sep 1;88 (17) :9934-46. |[4]Doyle C, et al. Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature. 1987 Nov 19-25;330 (6145) :256-9. |[5]Killeen N, et al. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 1993 Apr;12 (4) :1547-53.
Shipping Conditions
Room temperature in continental US; may vary elsewhere.
Storage Conditions
Stored at -20°C for 2 years
Scientific Category
Recombinant Proteins

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