Dapitant

CAT: 0804-HY-17012Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-17012Size:1 Each

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Description

Dapitant (RPR 100893) is a non-peptide Substance P antagonist with high affinity for the human NK1 receptor. It belongs to the 7,7,4-trimethylperhydroisoindole class of compounds. Dapitant inhibits the binding of Substance P to NK1 receptors, thereby blocking its neurokinin-mediated effects. This novel antagonist represents a potential therapeutic option for conditions involving Substance P, such as neurogenic inflammation and pain modulation[1].

CAS Number

153438-49-4

Product Name Alternative

RPR 100893

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dapitant.html

Smiles

COC1=CC=CC=C1[C@]2(O)CCC(C3=CC=CC=C3)(C4=CC=CC=C4)[C@]5([H])[C@@]2([H])CN(C([C@@H](C)C6=C(OC)C=CC=C6)=O)C5

Molecular Formula

C37H39NO4

Molecular Weight

561.71

References & Citations

[1]SYNTHESIS OF RPR 100893, PROTOTYPE OF A NEW SERIES OF POTENT AND SELECTIVE NON PEPTIDE NKl ANTAGONISTS : THE TRIARYLPERHYDROISOINDOLOLOLS

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Dapitant

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