β-Amanitin

• Description :

  β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) [1][2].

• UNSPSC :

  12352203

• Hazard Statement :

  H300+H310+H330

• Target :

  ADC Payload; DNA/RNA Synthesis

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/β-amanitin.html

• Purity :

  96.0

• Solubility :

  DMSO : 20 mg/mL (ultrasonic) |H2O : ≥ 10 mg/mL

• Smiles :

  OC1=CC=C(C2=C1)C(C[C@]3([H])NC([C@](NC([C@@]4([H])N(C[C@H](O)C4)C([C@@](CC(O)=O)([H])NC([C@](NC(CNC([C@@]([C@@H](C)CC)([H])NC(CNC3=O)=O)=O)=O)([H])C5)=O)=O)=O)([H])[C@@H](C)[C@@H](O)CO)=O)=C(N2)S5=O

• Molecular Formula :

  C39H53N9O15S

• Molecular Weight :

  919.95

• Precautions :

  P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

• References & Citations :

  [1]Kaya E, et al. Evaluation and comparison of alpha- and beta-amanitin toxicity on MCF-7 cell line. Turk J Med Sci. 2014;44 (5) :728-32.|[2]Lutz C, et al. Alpha- and Beta-Amanitin Total Synthesis. Angew Chem Int Ed Engl. 2020 Feb 24.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Traditional Cytotoxic Agents

• CAS Number :

  [21150-22-1]