β-Amanitin

• UNSPSC Description:

  β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2].

• Target Antigen:

  ADC Cytotoxin; DNA/RNA Synthesis

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/β-amanitin.html

• Purity:

  96.0

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC=C(C2=C1)C(C[C@]3([H])NC([C@](NC([C@@]4([H])N(C[C@H](O)C4)C([C@@](CC(O)=O)([H])NC([C@](NC(CNC([C@@]([C@@H](C)CC)([H])NC(CNC3=O)=O)=O)=O)([H])C5)=O)=O)=O)([H])[C@@H](C)[C@@H](O)CO)=O)=C(N2)S5=O

• Molecular Weight:

  919.95

• References & Citations:

  [1]Kaya E, et al. Evaluation and comparison of alpha- and beta-amanitin toxicity on MCF-7 cell line. Turk J Med Sci. 2014;44(5):728-32.|[2]Lutz C, et al. Alpha- and Beta-Amanitin Total Synthesis. Angew Chem Int Ed Engl. 2020 Feb 24.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  21150-22-1