β-Amanitin

CAT: 0804-HY-125586-01Size: 100 µgDry Ice: NoHazardous: No
CAT#:0804-HY-125586-01Size:100 µg
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Description
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) [1][2].
CAS Number
[21150-22-1]
UNSPSC
12352203
Hazard Statement
H300+H310+H330
Target
ADC Payload; DNA/RNA Synthesis
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/β-amanitin.html
Purity
96.0
Solubility
DMSO : 20 mg/mL (ultrasonic) |H2O : ≥ 10 mg/mL
Smiles
OC1=CC=C(C2=C1)C(C[C@]3([H])NC([C@](NC([C@@]4([H])N(C[C@H](O)C4)C([C@@](CC(O)=O)([H])NC([C@](NC(CNC([C@@]([C@@H](C)CC)([H])NC(CNC3=O)=O)=O)=O)([H])C5)=O)=O)=O)([H])[C@@H](C)[C@@H](O)CO)=O)=C(N2)S5=O
Molecular Formula
C39H53N9O15S
Molecular Weight
919.95
Precautions
P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
References & Citations
[1]Kaya E, et al. Evaluation and comparison of alpha- and beta-amanitin toxicity on MCF-7 cell line. Turk J Med Sci. 2014;44 (5) :728-32.|[2]Lutz C, et al. Alpha- and Beta-Amanitin Total Synthesis. Angew Chem Int Ed Engl. 2020 Feb 24.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents

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