Perphenazine

• Description :

  Perphenazine is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine also binds to Alpha-1A adrenergic receptor. Perphenazine inhibits cancer cell proliferation, and induces apoptosis. Perphenazine can be used in the research of mental disease, cancer, inflammation[1][3][5].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H317

• Target :

  5-HT Receptor; Adrenergic Receptor; Apoptosis; Autophagy; Dopamine Receptor; Histamine Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer; Endocrinology; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Perphenazine.html

• Purity :

  99.95

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles :

  OCCN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(Cl)C=C24)CC1

• Molecular Formula :

  C21H26ClN3OS

• Molecular Weight :

  403.97

• Precautions :

  H302, H317

• References & Citations :

  [1]Richtand NM, et al. Dopamine and serotonin receptor binding and antipsychotic efficacy. Neuropsychopharmacology. 2007 Aug;32 (8) :1715-26.|[2]Lei Tao, et al. Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo. Toxicol Lett. 2022 Jul 29;367:76-87. |[3]Min-Jeong Heo, et al. Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis. Int J Mol Sci. 2020 May 3;21 (9) :3241. |[4]Michał Otręba, et al. Perphenazine and prochlorperazine decrease glioblastoma U-87 MG cell migration and invasion: Analysis of the ABCB1 and ABCG2 transporters, E-cadherin, α-tubulin and integrins (α3, α5, and β1) levels. Oncol Lett. 2022 Jun;23 (6) :182. |[5]Michał Otręba, et al. n vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review. J Appl Toxicol. 2021 Jan;41 (1) :82-94.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT2 Receptor; D2 Receptor; D3 Receptor; D4 Receptor; H2 Receptor; mLAG-3; MUC2; MUC3; α-1 microglobulin

• CAS Number :

  [58-39-9]