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Rilapladib

CAT: 0804-HY-102004-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-102004-01Size:5 mg
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Description
Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM[1]. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist[2].
CAS Number
412950-08-4
Product Name Alternative
SB 659032
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Rilapladib.html
Purity
99.44
Solubility
DMSO : 86.67 mg/mL (ultrasonic)
Smiles
O=C(N(C1CCN(CCOC)CC1)CC2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)CN4C(SCC5=CC=CC(F)=C5F)=CC(C6=C4C=CC=C6)=O
Molecular Formula
C40H38F5N3O3S
Molecular Weight
735.81
References & Citations
[1]Shaddinger BC, et al. Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials. PLoS One. 2014 Jan 27;9 (1) :e83094.|[2]Athanasios Papakyriakou, et al. Computational Investigation of Darapladib and Rilapladib Binding to Platelet Activating Factor Receptor. A Possible Mechanism of Their Involvement in Atherosclerosis. International Journal of Chemistry; Vol. 6, No. 1; 2014.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
BA8253-5.1Rilapladib
A13229-50Rilapladib 50mg
A13229-25Rilapladib 25mg
A13229-5Rilapladib 5mg
A13229-1Rilapladib 1mg
A13229-10Rilapladib 10mg
A13229-100Rilapladib 100mg
A13229-10mM-DRilapladib 10mM * 1mL in DMSO

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