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Felbinac

CAT: 0804-HY-B0641-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0641-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase (COX) inhibitor with an IC50 of 865.68 nM for COX1 and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity[2][3][4].
CAS Number
5728-52-9
Product Name Alternative
4-Biphenylacetic acid
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Felbinac.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
O=C(O)CC1=CC=C(C2=CC=CC=C2)C=C1
Molecular Formula
C14H12O2
Molecular Weight
212.25
Precautions
H301, H315, H319, H335
References & Citations
[1]Van Eerdenbrugh B, et al. 2- (Biphenyl-4-yl) acetic acid (felbinac) . Acta Crystallogr Sect E Struct Rep Online.|[2]Bhagyashri Kasabe, et al. Drug repurposing approach against chikungunya virus: an in vitro and in silico study. Front Cell Infect Microbiol. 2023 Apr 27:13:1132538. |[3]Fumiyo Kasuya, et al. Effect of enoxacin, felbinac, and sparfloxacin on fatty acid metabolism and glucose concentrations in rat tissues. Int J Toxicol. 2011 May;30 (3) :367-76.|[4]Shah Alam Khan, et al. Synthesis, molecular docking with COX 1& II enzyme, ADMET screening and in vivo anti-inflammatory activity of oxadiazole, thiadiazole and triazole analogs of felbinac.Journal of Saudi Chemical Society. Volume 22, Issue 4
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2

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