Cycleanine

CAT: 0804-HY-N2005-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-N2005-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[1][2].

CAS Number

518-94-5

UNSPSC

12352005

Target

Apoptosis; Calcium Channel

Type

Natural Products

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cycleanine.html

Purity

99.80

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(OC2=CC=C(C[C@](N(CC3)C)([H])C4=C3C=C5OC)C=C2)C([C@@](N6C)([H])CC7=CC=C(OC4=C5OC)C=C7)=C(CC6)C=C1OC

Molecular Formula

C38H42N2O6

Molecular Weight

622.75

References & Citations

[1]Martínez JA, et al. Calcium antagonist properties of the bisbenzylisoquinoline alkaloid cycleanine. Fundam Clin Pharmacol. 1998;12 (2) :182-7.|[2]Uche FI, et al. Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytother Res. 2016 Sep;30 (9) :1533-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

L-type calcium channel

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