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OXSI-2

CAT: 0804-HY-112386-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-112386-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM[1][2].
CAS Number
622387-85-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Syk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/oxsi-2.html
Purity
95.00
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
O=S(C1=CC2=C(NC(/C2=C/C3=CN(C)C4=C3C=CC=C4)=O)C=C1)(N)=O
Molecular Formula
C18H15N3O3S
Molecular Weight
353.40
Precautions
H315, H319, H335
References & Citations
[1]Kamala Bhavaraju, et al. Evaluation of [3- (1-methyl-1H-indol-3-yl-methylene) -2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets. Eur J Pharmacol. 2008 Feb 12;580 (3) :285-90.|[2]Jordan R Yaron, et al. The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochem Biophys Res Commun. 2016 Apr 8;472 (3) :545-50.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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