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Methylergometrine

CAT: 0804-HY-153027Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153027Size:1 Each
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Description
Methylergometrine (Methylergonovine) is an orally active 5-HT2B ligand agonist. The distribution half-life of Methylergometrine is only 1-2 min. Methylergometrine can be used as an oxytocin to treat uterine atony[1][2][3].
CAS Number
113-42-8
Product Name Alternative
Methylergonovine; Ryegonovin (free base) ; Spametrin F (free base)
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/methylergometrine.html
Solubility
10 mM in DMSO
Smiles
[H][C@]1(C2=C[C@@H](C(N[C@H](CO)CC)=O)CN1C)CC3=CNC4=C3C2=CC=C4
Molecular Formula
C20H25N3O2
Molecular Weight
339.43
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Hajjo R, et al. Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs. J Med Chem. 2010 Nov 11;53 (21) :7573-86. |[2]Amant F, et al. Misoprostol compared with methylergometrine for the prevention of postpartum haemorrhage: a double-blind randomised trial. Br J Obstet Gynaecol. 1999 Oct;106 (10) :1066-70. |[3]Mäntylä R, et al. Plasma and tissue concentrations of methylergometrine (methylergonovine) in the rabbit. Acta Pharmacol Toxicol (Copenh) . 1980 Apr;46 (4) :245-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
5-HT2 Receptor; α-1 microglobulin

Alternative Products

CatalogName
RM-M052200-01Methylergometrine
T21429-01Methylergometrine maleate
AR-M01632-01Methylergonovine (Methylergometrine)
AR-M01636-01Methylergometrine EP impurity A
AR-M03489-01Methylergometrine EP Impurity E
AR-M01638-01Methylergometrine EP impurity C
AR-M03494-01Methylergometrine EP Impurity I
AR-M01637-01Methylergometrine EP impurity B
AR-M01642-01Methylergometrine EP impurity G
AR-M03493-01Methylergometrine EP Impurity H

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