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Tenatoprazole

CAT: 0804-HY-17421-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17421-01Size:5 mg
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Description
Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H+/K+-ATPase activity with an IC50 of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV[1][2][3].
CAS Number
113712-98-4
Product Name Alternative
TU-199
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Proton Pump
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tenatoprazole.html
Purity
99.75
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=NC2=CC=C(OC)N=C2N1)CC3=NC=C(C)C(OC)=C3C
Molecular Formula
C16H18N4O3S
Molecular Weight
346.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Thomson AB, et al. Comparison of the effects of fasting morning, fasting evening and fed bedtime administration of tenatoprazole on intragastric pH in healthy volunteers: a randomized three-way crossover study. Aliment Pharmacol Ther. 2006;23 (8) :1179-1187.|[2]Uchiyama K, et al. Effects of TU-199, a novel H+, K (+) -ATPase inhibitor, on gastric acid secretion and gastroduodenal ulcers in rats. Methods Find Exp Clin Pharmacol. 1999;21 (2) :115-122.|[3]Mannemuddhu SS, et al. Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency. J Virol. 2021;95 (13) :e0246620.|[4]Uchiyama K, et al. The long-lasting effect of TU-199, a novel H+, K (+) -ATPase inhibitor, on gastric acid secretion in dogs. J Pharm Pharmacol. 1999;51 (4) :457-464.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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