Trastuzumab emtansine
CAT:
804-HY-P9921-02
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: Yes
Trastuzumab emtansine
- CAS Number: 1018448-65-1
- UNSPSC Description: Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer[1][2].
- Target Antigen: Antibody-Drug Conjugates (ADCs); EGFR
- Type: ADC Related
- Related Pathways: Antibody-drug Conjugate/ADC Related;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/trastuzumab-emtansine.html
- Purity: 99.74
- Solubility: H2O
- Smiles: [Trastuzumab emtansine]
- Molecular Weight: 148000 (average)
- References & Citations: [1]Verma S, et, al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 2012 Nov 8;367(19):1783-91.|[2]Menderes G, et, al. Superior in vitro and in vivo activity of trastuzumab-emtansine (T-DM1) in comparison to trastuzumab, pertuzumab and their combination in epithelial ovarian carcinoma with high HER2/neu expression. Gynecol Oncol. 2017 Oct;147(1):145-152.
- Shipping Conditions: Dry Ice
- Storage Conditions: -80°C, protect from light
- Clinical Information: Launched