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GSK4112

CAT: 0804-HY-14414-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14414-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways[1].
CAS Number
1216744-19-2
Product Name Alternative
SR6452
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; REV-ERB
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/GSK4112.html
Purity
99.87
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(CN(CC2=CC=C([N+]([O-])=O)S2)CC(OC(C)(C)C)=O)C=C1
Molecular Formula
C18H21ClN2O4S
Molecular Weight
396.89
Precautions
H302, H315, H319, H335
References & Citations
[1]Grant D, et al. GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. ACS Chem Biol. 2010 Oct 15;5 (10) :925-932.|[2]Shao R, et al. REV-ERBα Agonist GSK4112 attenuates Fas-induced Acute Hepatic Damage in Mice. Int J Med Sci. 2021 Oct 25;18 (16) :3831-3838.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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