Sisomicin (sulfate)

• UNSPSC Description:

  Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria[1][2][3][4].

• Target Antigen:

  Antibiotic; Bacterial

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Sisomicin-sulfate.html

• Purity:

  99.15

• Solubility:

  H2O : 125 mg/mL (ultrasonic)

• Smiles:

  N[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H]2O)([H])OC(CN)=CC1.[2.5H2SO4]

• Molecular Weight:

  692.72

• References & Citations:

  [1]P Noone, et al. Sisomicin, netilmicin and dibekacin. A review of their antibacterial activity and therapeutic use. Drugs. 1984 Jun;27(6):548-78.|[2]Crowe CC, et al. Sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin. Antimicrob Agents Chemother. 1973 Jan;3(1):24-8.|[3]Le Moli S, et al. In vitro and in vivo effect of sisomicin and gentamycin on polymorphonuclear chemotaxis and phagocytosis. Int J Immunopharmacol. 1983;5(1):49-54.|[4]Fabre J, et al. Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats. Kidney Int. 1976 Dec;10(6):444-9.ACS Biomater Sci Eng. 2024 Apr 24.|Curr Microbiol. 2021 Dec 14;79(1):12.|Research Square Preprint. 2024 Apr 1.|STAR Protoc. 2024 Jun 7;5(2):103118.|ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  53179-09-2