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NAMI-A

CAT: 0804-HY-19376-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-19376-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NAMI-A is a ruthenium-based agent characterized by selective activity against tumor metastasis, inhibiting adhesion and migration.
CAS Number
201653-76-1
UNSPSC
12352005
Target
FAK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NAMI-A.html
Concentration
10mM
Purity
98.0
Solubility
H2O : 8.28 mg/mL (ultrasonic; warming)
Smiles
Cl[Ru](Cl)(Cl)(Cl)(C)[N]1=CNC=C1.O=S(C)C.[H+].C2=CNC=N2
Molecular Formula
C5H10Cl4N2ORuS.C3H4N2.H
Molecular Weight
458.18
References & Citations
[1]Sava G et al. Dual Action of NAMI-A in inhibition of solid tumor metastasis: selective targeting of metastatic cells and binding to collagen. Clin Cancer Res. 2003 May;9 (5) :1898-905.|[2]Pelillo C et al. Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. J Inorg Biochem. 2016 Jul;160:225-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Nami-A
CAS Number201653-76-1
PubChem CID133082692
IUPAC Name1H-imidazole;1H-imidazol-3-ium;methylsulfinylmethane;ruthenium(3+);tetrachloride
Molecular FormulaC8H15Cl4N4ORuS
Molecular Weight458.2
Topological Polar Surface Area94.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count0
Heavy Atom Count19
Formal Charge0
Complexity81
SMILES
CS(=O)C.C1=C[NH+]=CN1.C1=CN=CN1.[Cl-].[Cl-].[Cl-].[Cl-].[Ru+3]
InChI
InChI=1S/2C3H4N2.C2H6OS.4ClH.Ru/c2*1-2-5-3-4-1;1-4(2)3;;;;;/h2*1-3H,(H,4,5);1-2H3;4*1H;/q;;;;;;;+3/p-3
InChIKey
RJZBTXZRLXLLKO-UHFFFAOYSA-K
Chemical Structure
2D Structure
2D structure of Nami-A
CAS: 201653-76-1
CID: 133082692
Formula: C8H15Cl4N4ORuS
MW: 458.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight458.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count0
Exact Mass458.873458
Monoisotopic Mass456.876408
Topological Polar Surface Area94.9 Ų
Heavy Atom Count19
Formal Charge0
Complexity81.2
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count8
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA8930-10NAMI-A
A12143-100NAMI-A 100mg
A12143-50NAMI-A 50mg
A12143-1NAMI-A 1mg
A12143-25NAMI-A 25mg
A12143-10NAMI-A 10mg
A12143-5NAMI-A 5mg

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