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Vaxfectin

CAT: 0804-HY-142998-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-142998-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vaxfectin is a second-generation cationic lipid-based suspension that adjuvants effectively both pDNA and protein-based vaccines. Vaxfectin can boost the immune response against a range of pDNA-expressed pathogenic antigens in vivo. Vaxfectin can increase IgG titers and give rise to an IL-6 dependent enhancement of the humoral immune response without altering the Th1 type immune response. Vaxfectin can be studied for vaccine formulation[1][2][3].
CAS Number
370108-99-9
UNSPSC
12352200
Target
IFNAR; Interleukin Related; Liposome
Type
Biochemical Assay Reagents
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vaxfectin.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCOP(OC[C@H](OC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)COC(CC(C)CCCC(C)CCCC(C)CCCC(C)C)=O)(O)=O.CCCC/C=C\CCCCCCCCOCC(C[N+](C)(C)CCCN)OCCCCCCCC/C=C\CCCC.[Br-]
Molecular Formula
C81H163BrN3O10P
Molecular Weight
1450.05
References & Citations
[1]Sullivan SM, et, al. Vaxfectin: a versatile adjuvant for plasmid DNA- and protein-based vaccines. Expert Opin Drug Deliv. 2010 Dec;7 (12) :1433-46.|[2]Hartikka, J., et al., (2001) . Vaxfectin enhances the humoral immune response to plasmid DNA-encoded antigens. Vaccine, 19 (15-16), 1911–1923.|[3]Reyes, L., et al., (2001) . Vaxfectin enhances antigen specific antibody titers and maintains Th1 type immune responses to plasmid DNA immunization. Vaccine, 19 (27), 3778–3786.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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