(1R,9R)-Exatecan (mesylate)

(1R,9R)-Exatecan (mesylate)

• CAS Number: 2938875-39-7
• UNSPSC Description: (1R,9R)-Exatecan mesylate((1R,9R)-DX8951f) is an isomer of Exatecan mesylate (HY-13631A). Exatecan mesylate (DX8951f) is an inhibitor of DNA topoisomerase I with an IC50 of 2.2 μM (0.975 μg/mL) and can be used in cancer research[1].
• Target Antigen: ADC Cytotoxin; Topoisomerase
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/1r-9r-exatecan-mesylate.html
• Smiles: O=S(C)(O)=O.O=C1[C@@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O
• Molecular Weight: 531.55
• References & Citations: [1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.
• Shipping Conditions: Room Temperature