BWC0977

• Description :

  BWC0977 is an antibacterial agent that inhibits bacterial DNA replication via inhibition of DNA gyrase and topoisomerase IV. BWC0977 exhibits a minimum inhibitory concentration (MIC90) of 0.03-2 µg/mL against MDR (Multi-Drug Resistant) Gram-negative bacteria[1].

• UNSPSC :

  12352101

• Target :

  Bacterial; DNA/RNA Synthesis; Topoisomerase

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/bwc0977.html

• Smiles :

  O=C1N(C)C2=C(CCNC[C@H]3CN(C4=CN=C(OCC(N5)=O)C5=N4)C(O3)=O)C(F)=CC=C2C=C1

• Molecular Formula :

  C22H21FN6O5

• Molecular Weight :

  468.44

• References & Citations :

  [1]Shahul Hameed P, et al. BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections. Clinical Trial Nat Commun. 2024 Sep 18;15 (1) :8202.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  Topoisomerase

• CAS Number :

  [2254567-00-3]