Taurochenodeoxycholic acid-d5 (sodium)

Taurochenodeoxycholic acid-d5 (sodium)

• UNSPSC Description: Taurochenodeoxycholic acid-d5 (sodium) is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
• Target Antigen: Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease;Others
• Field of Research: Inflammation/Immunology
• Purity: 98.12
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming)
• Smiles: C[C@]12[C@]([H])([C@]3([C@@]([H])([C@]4(C)[C@]([H])(C[C@H]3O)C([2H])([C@]([2H])(O)C([2H])(C4)[2H])[2H])CC2)[H])CC[C@@]1([C@@H](CCC(NCCS(=O)(O[Na])=O)=O)C)[H]
• Molecular Weight: 526.72
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Wang X, et al. Taurochenodeoxycholic acid induces NR8383 cells apoptosis via PKC/JNK-dependent pathway. Eur J Pharmacol. 2016 Sep 5;786:109-15.|[3]Zhou C, et al. The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice. Pak J Pharm Sci. 2013 Jul;26(4):761-5.|[4]Uchida A, et al. Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation. Am J Physiol. 1997 May;272(5 Pt 1):G1249-57.|[5]Liu M, et al. Effects of taurochenodeoxycholic acid on adjuvant arthritis in rats. Int Immunopharmacol. 2011 Dec;11(12):2150-8.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported