Enpp-1-IN-19
CAT:
804-HY-155457-05
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Enpp-1-IN-19
- CAS Number: 2738583-25-8
- UNSPSC Description: Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1].
- Target Antigen: Phosphodiesterase (PDE); STING
- Type: Reference compound
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: cancer
- Assay Protocol: https://www.medchemexpress.com/enpp-1-in-19.html
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: O=C1C2=CC=CC=C2C(CC3=CC=C(NS(=O)(N)=O)C=C3)=NN1C
- Molecular Weight: 344.39
- References & Citations: [1]Cho Y et al. Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy. J Med Chem. 2023 Nov 23;66(22):15141-15170.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported