Enpp-1-IN-19

Enpp-1-IN-19

• CAS Number: 2738583-25-8
• UNSPSC Description: Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1].
• Target Antigen: Phosphodiesterase (PDE); STING
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/enpp-1-in-19.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C1C2=CC=CC=C2C(CC3=CC=C(NS(=O)(N)=O)C=C3)=NN1C
• Molecular Weight: 344.39
• References & Citations: [1]Cho Y et al. Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy. J Med Chem. 2023 Nov 23;66(22):15141-15170.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported