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IC261

CAT: 0804-HY-12774-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12774-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IC261 is a selective, ATP-competitive CK1 inhibitor, with IC50s of 1 μM, 1 μM, 16 μM for Ckiδ, Ckiε and Ckiα1, respectively.
CAS Number
186611-52-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Casein Kinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IC261.html
Purity
99.63
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NC2=C(C=CC=C2)/C1=C\C3=C(OC)C=C(OC)C=C3OC
Molecular Formula
C18H17NO4
Molecular Weight
311.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Mashhoon N, et al. Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275 (26) :20052-60.|[2]Stöter M, et al. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene. 2005 Dec 1;24 (54) :7964-75.|[3]Brockschmidt C, et al. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut. 2008 Jun;57 (6) :799-806.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1

Chemical Information

IC261

a caseine kinase-1 inhibitor; structure in first source

CAS Number186611-52-9
PubChem CID5288600
IUPAC Name(3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one
Molecular FormulaC18H17NO4
Molecular Weight311.3
XLogP2.8
Topological Polar Surface Area56.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity450
SMILES
COC1=CC(=C(C(=C1)OC)/C=C/2\C3=CC=CC=C3NC2=O)OC
InChI
InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10+
InChIKey
JBJYTZXCZDNOJW-JLHYYAGUSA-N
Chemical Structure
2D Structure
2D structure of IC261
CAS: 186611-52-9
CID: 5288600
Formula: C18H17NO4
MW: 311.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight311.3
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass311.11575802
Monoisotopic Mass311.11575802
Topological Polar Surface Area56.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity450
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B6108-10IC261

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