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Pyributicarb

CAT: 0804-HY-111202-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111202-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR) .
CAS Number
88678-67-5
Product Name Alternative
TSH-888
UNSPSC
12352005
Hazard Statement
H410
Target
Cytochrome P450; Pregnane X Receptor (PXR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Pyributicarb.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
S=C(OC1=CC=CC(C(C)(C)C)=C1)N(C2=NC(OC)=CC=C2)C
Molecular Formula
C18H22N2O2S
Molecular Weight
330.44
Precautions
H410
References & Citations
[1]Matsubara T, et al. Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene. Drug Metab Dispos. 2007 May;35 (5) :728-33.|[2]Kojima H, et al. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27;280 (3) :77-87.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP3

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