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α-Arbutin

CAT: 0804-HY-N3002-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3002-01Size:50 mg
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Description
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a tyrosinase inhibitor, which is used as an effective skin whiteners. α-Arbutin is promising for research of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes[1][2][3][4].
CAS Number
84380-01-8
Product Name Alternative
4-Hydroxyphenyl α-D-glucopyranoside
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Tyrosinase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/α-arbutin.html
Concentration
10mM
Purity
99.98
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
OC(C=C1)=CC=C1O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO
Molecular Formula
C12H16O7
Molecular Weight
272.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Avonto C, et al. Comparative studies on the chemical and enzymatic stability of alpha- and beta-arbutin.Int J Cosmet Sci. 2016 Apr;38 (2) :187-93.|[2]Saeedi M, et al. A comprehensive review of the therapeutic potential of α-arbutin. Phytother Res. 2021 Aug;35 (8) :4136-4154. |[3]Sugimoto K, et al. Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model. Biol Pharm Bull. 2004 Apr;27 (4) :510-4.|[4]Hazman Ö, et al. Two faces of arbutin in hepatocellular carcinoma (HepG2) cells: Anticarcinogenic effect in high concentration and protective effect against cisplatin toxicity through its antioxidant and anti-inflammatory activity in low concentration[J]. Biologia, 2022, 77 (1) : 225-239.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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