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Mufemilast

CAT: 0804-HY-145583-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145583-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mufemilast (Heymay005) is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor (IC50 = 80-120 nM) . Mufemilast modulates cytokines upregulated in Behςet’s syndrome (BS) . Mufemilast displays a significant inhibitory effect on TNF-α, which is an important proinflammatory cytokine target in the disease process of psoriasis. Mufemilast can be studied in research for diseases such as rheumatoid arthritis, psoriasis and BS[1][2][3][4][5].
CAS Number
1255909-03-5
Product Name Alternative
Hemay005
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/mufemilast.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(NC(C)=O)SC=C2C(N1[C@@H](C3=CC(OCC)=C(C=C3)OC)CS(C)(=O)=O)=O
Molecular Formula
C20H22N2O7S2
Molecular Weight
466.53
References & Citations
[1]Liu Tian, et al., Efficacy and Safety of Mufemilast in Patients with Behçet's Syndrome: A Phase 2, Double-Blind, Placebo-Controlled Trial. |[2]Yilmaz, O., et al., (2024) . New and emerging oral therapies for psoriasis. Drugs in context, 13, 2024-5-6.|[3]Peng, T., et al., (2020) . Advances in the Development of Phosphodiesterase-4 Inhibitors. Journal of medicinal chemistry, 63 (19), 10594–10617.|[4]Liu, X., et al., (2018) . Determination of a PDE4 inhibitor Hemay005 in human plasma and urine by UPLC-MS/MS and its application to a PK study. Bioanalysis, 10 (11), 863–875. |[5]Liu, X., et al., (2018) . Determination of a PDE4 inhibitor Hemay005 in human plasma and urine by UPLC-MS/MS and its application to a PK study. Bioanalysis, 10 (11), 863–875.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PDE4

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CatalogName
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