Silybin A

• Description:

  Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

• Product Name Alternative:

  Silibinin A

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/silybin-a.html

• Purity:

  99.94

• Solubility:

  DMSO : 233.33 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@H] (O) [C@@H] (C2=CC=C (O[C@H] (CO) [C@@H] (C3=CC=C (O) C (OC) =C3) O4) C4=C2) OC5=CC (O) =CC (O) =C15

• Molecular Formula:

  C25H22O10

• Molecular Weight:

  482.44

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Woo SM, et al. Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1) -mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. Chem Biol Interact. 2014 Jan 16;211C:36-43.|[2]Kim TH, et al. Silibinin induces cell death through ROS-dependent down-regulation of Notch-1/ERK/Akt signaling in human breast cancer cells. J Pharmacol Exp Ther. 2014 Jan 28.|[3]Zhang S, et al. Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PLoS One. 2013 Dec 27;8 (12) :e83699.|[4]Khan AQ, et al. Silibinin Inhibits Tumor Promotional Triggers and Tumorigenesis Against Chemically Induced Two-Stage Skin Carcinogenesis in Swiss Albino Mice: Possible Role of Oxidative Stress and Inflammation. Nutr Cancer. 2013 Dec 23.|[5]Khazim K, et al. The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo. Am J Physiol Renal Physiol. 2013 Sep 1;305 (5) :F691-700.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• CAS Number:

  22888-70-6