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Thiothixene

CAT: 0804-HY-A0139Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0139Size:1 mg
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Description
Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively) . Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM) . In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.
CAS Number
5591-45-7
Product Name Alternative
NSC 108165; Navan; Navane
UNSPSC
12352005
Hazard Statement
H302-H351
Target
Adrenergic Receptor; Dopamine Receptor; Histamine Receptor; mAChR; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/thiothixene.html
Smiles
O=S(C1=CC(/C2=C/CCN3CCN(C)CC3)=C(SC4=C2C=CC=C4)C=C1)(N(C)C)=O
Molecular Formula
C23H29N3O2S2
Molecular Weight
443.63
Precautions
P264-P270-P280-P330-P405-P501
References & Citations
[1]Silvestre, et al. Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes. Methods Find. Exp. Clin. Pharmacol. 27 (5), 289-304 (2005) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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