Plerixafor (octahydrochloride)

Plerixafor (octahydrochloride)

• CAS Number: 155148-31-5
• UNSPSC Description: Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC50 of 44 nM.
• Target Antigen: CXCR; HIV; Virus Protease
• Type: Reference compound
• Related Pathways: Anti-infection;GPCR/G Protein;Immunology/Inflammation
• Applications: COVID-19-anti-virus
• Field of Research: Inflammation/Immunology; Endocrinology; Cancer
• Assay Protocol: https://www.medchemexpress.com/Plerixafor-octahydrochloride.html
• Purity: 99.09
• Solubility: DMSO : < 1 mg/mL|H2O : 100 mg/mL (ultrasonic)
• Smiles: [H]Cl.N1(CCCNCCNCCCNCC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.[8]
• Molecular Weight: 794.47
• References & Citations: [1]Zabel BA, et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 2009 Sep 1;183(5):3204-11.|[2]Mercurio L, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016 Mar 25;35:55.|[3]Yang J, et al. Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation. PLoS One. 2016 Feb 22;11(2):e0149926.|[4]Chu PY, et al. CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS One. 2015 Jul 27;10(7):e0133616.|[5]Schols D, et al. HIV co-receptor inhibitors as novel class of anti-HIV drugs. Antiviral Res. 2006 Sep;71(2-3):216-26.Adv Funct Mater. 2020, 2000309.|Anticancer Drugs. 2017 Oct;28(9):935-942.|Brain Behav Immun. 2017 Jan;59:322-332.|Mater Today Bio. 2024 Sep 1:28:101222.|Mol Ther-Nucl Acids. 2023 Mar 9.|Oncogene. 2022 Oct;41(41):4633-4644.|Oxid Med Cell Longev. 2021 Aug 2;2021:9993240.|Patent. US20190133998A1.|Pharmaceutics. 2021 Mar 24;13(4):439.|Ruprecht-Karls-University Heidelberg. 2023 Aug 3.|ACS Infect Dis. 2023 Oct 5.|Acta Biomater. 2024 Feb 13:S1742-7061(24)00067-9.|Acta Biomater. 2024 Jul 17:S1742-7061(24)00395-7.|Andrology. 2022 Sep 16.|Bioact Mater. 2021 Jan 7;6(7):2039-2057.|Biochem Biophys Res Commun. 2021 Jan 1;534:337-342.|Biomed Pharmacother. 2020, 110610.|Biomolecules. 2024 Sep 25;14(10):1206.|BMC Complement Altern Med. 2018 Dec 12;18(1):330. |Br J Haematol. 2022 Dec 19.|Cancer Lett. 2022 Oct 7;551:215944.|Cell Death Dis. 2017 Jan 19;8(1):e2560. |Cell Death Dis. 2022 Feb 4;13(2):118.|Cell Death Dis. 2023 Mar 28;14(3):219.|Cell Mol Immunol. 2020 Mar;17(3):283-299.|Cell Mol Life Sci. 2024 Mar 13;81(1):132.|Cell Physiol Biochem. 2018;46(3):890-906. |Cell Signal. 2020 Feb;66:109488.|Cell Tissue Res. 2020 Jun;380(3):469-486.|Cell Transplant. 2022 Jan-Dec;31:9636897221129171.|Cells. 2019 Jul 22;8(7):761.|Cells. 2022 Jan 4;11(1):155.|Chinese Journal of Tissue Engineering Research. 2014,18(45): 7327-7332.|Drug Des Devel Ther. 2022 Jan 6;16:67-81.|Exp Ther Med. July 19, 2021.|Fertil Steril. 2020 May;113(5):1067-1079.e5.|Immunity. 2024 Feb 13;57(2):364-378.e9.|Int J Biol Sci. 2017 May 5;13(5):604-614.|Int J Mol Sci. 2023 Aug 13, 24(16), 12740.|Int J Mol Sci. 2024 Jul 1;25(13):7254.|Int J Mol Sci. 2024 May 4;25(9):5018.|Int J Nanomedicine. 2023 Jul 31;18:4329-4346.|J Diabetes Complicat. 2020 Oct;34(10):107654.|J Mater Chem B. 2018 Apr 7;6(13):1951-1964. |J Oncol. 08 Oct 2021.|J Steroid Biochem Mol Biol. 2021 Jun 3;105926.|J Transl Med. 2023 Sep 5;21(1):593.|Kaohsiung J Med Sci. 2021 Nov 6.|Ludwig maxime clinic. University of Munich. 2019 Apr.|Mol Med Rep. 2020 Oct;22(4):3201-3212.|Nano Today. 2022, 47: 101689.|Nat Cell Biol. 2024 Jul 22.|Oncogene. 2019 Jun;38(25):5021-5037. |Oncol Lett. 2018 Sep;16(3):3976-3982. |Patent. US20200360478A1.|PLoS One. 2021 Mar 1;16(3):e0247707.|Research Square Preprint. 2021 Aug.|Research Square Preprint. 2021 Sep.|Research Square Preprint. 2022 Jul.|Research Square Preprint. 2023 Oct 23.|SSRN. 5 Feb 2022.|Stem Cells Int. 2020 Jul 7;2020:1498315.|Theranostics. 2021 Jan 1;11(6):2612-2633.|Transl Stroke Res. 2021 Jun 25.|Universität Hamburg. Informatics and Natural Sciences. 2021 Mar 19.|University of Zagreb. 2024 May 23.|Uppsala University. Department of Pharmaceutical Biosciences. 2022 Feb.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched