Se2h

CAT: 0804-HY-159915Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-159915Size:1 Each

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Description

Se2h is a cruzain inhibitor that exhibits strong activity against the intracellular amastigotes of Trypanosoma cruzi (EC50 SI > 10), with an inhibitory activity against cruzain of IC50 SI > 5.55). Compared to Benznidazole and the cruzain inhibitor K777 (HY-119293), Se2h shows superior selectivity and inhibition, while its selenazole structure reduces selenium-related toxicity. Se2h exhibits antiparasitic activity and holds promise for research in Chagas disease[1].

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/se2h.html

Smiles

C/C(C1=CC=CC([N+]([O-])=O)=C1)=N\NC2=NC(C)=C[Se]2.Cl

Molecular Formula

C12H13ClN4O2Se

Molecular Weight

359.67

References & Citations

[1]Rubio-Hernández M, et al. Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (S, Se) and Their Azole Derivatives against Chagas Disease. J Med Chem. 2024 Nov 14;67 (21) :19038-19056.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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