Products for Research Use Only
RegisterLogin

Quiflapon

CAT: 0804-HY-10037-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10037-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC50 values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis[1][2].
CAS Number
136668-42-3
Product Name Alternative
MK-591
UNSPSC
12352005
Target
Apoptosis; FLAP
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/MK-0591.html
Purity
99.76
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(O)C(C)(C)CC1=C(SC(C)(C)C)C2=C(C=CC(OCC3=NC4=CC=CC=C4C=C3)=C2)N1CC5=CC=C(Cl)C=C5
Molecular Formula
C34H35ClN2O3S
Molecular Weight
587.17
References & Citations
[1]Brideau C, et al. Pharmacology of MK-0591 (3-[1- (4-chlorobenzyl) -3- (t-butylthio) -5- (quinolin-2-yl-methoxy) - indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1992 Jun;70 (6) :799-807.|[2]Park MS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner. Lung. 2011 Feb;189 (1) :43-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
LFA66842-01Quiflapon
TQ0098-01Quiflapon sodium
596640Quiflapon free acid
MBS3840890-01MK-0591 (Quiflapon)
A15163-25MK-0591 (Quiflapon) 25mg
A15163-5MK-0591 (Quiflapon) 5mg
A15163-100MK-0591 (Quiflapon) 100mg
A15163-2MK-0591 (Quiflapon) 2mg
A15163-1MK-0591 (Quiflapon) 1mg
A15163-10mM-DMK-0591 (Quiflapon) 10mM * 1mL in DMSO

Popular Products