Batimastat

• Description:

  Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.

• Product Name Alternative:

  BB94

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  MMP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Batimastat.html

• Concentration:

  10mM

• Purity:

  98.92

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 70°C)

• Smiles:

  O=C (N[C@@H] (CC1=CC=CC=C1) C (NC) =O) [C@H] (CC (C) C) [C@H] (CSC2=CC=CS2) C (NO) =O

• Molecular Formula:

  C23H31N3O4S2

• Molecular Weight:

  477.64

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303 (1) :E55-70.|[2]Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93 (7) :2749-54.|[3]Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98 (2) :210-5.|[4]Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4 (4) :985-92.|[5]Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726.|[6]Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  130370-60-4