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Vigabatrin

CAT: 0804-HY-15399-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15399-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].
CAS Number
68506-86-5
Product Name Alternative
γ-Vinyl-GABA
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vigabatrin.html
Purity
98.0
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
C=CC(N)CCC(O)=O
Molecular Formula
C6H11NO2
Molecular Weight
129.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46 (2), 362-376.|[2]Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12 (3), 275-286.|[3]Jakob Plum, et al. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models. Int J Pharm. 2014 Oct 1;473 (1-2) :395-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
BA6653-50Vigabatrin

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