Amiodarone

CAT: 0804-HY-14187-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14187-01Size:5 mg
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Description
Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
CAS Number
[1951-25-3]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Autophagy; Potassium Channel
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Amiodarone.html
Purity
98.32
Solubility
DMSO : ≥ 175 mg/mL
Smiles
CCCCC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=C(O1)C=CC=C3
Molecular Formula
C25H29I2NO3
Molecular Weight
645.31
Precautions
H315, H319, H320
References & Citations
[1]Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39 (4) : p. 657-67.|[2]Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38 (7) : p. 934-44.|[3]Wilson BD, et al. Amiodarone-induced pulmonary toxicity in the rat. Lung. 1989;167 (5) :301-11.|[4]Plomp TA, et al. Pharmacokinetics and body distribution of amiodarone and desethylamiodarone in rats after oral administration. In Vivo. 1987 Sep-Oct;1 (5) :265-79.|[5]Takai S, et al. Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism. J Appl Toxicol. 2016 Jan;36 (1) :35-47.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Biochem Biophys Res Commun. 2020 Feb 19;522 (4) :862-868.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Cell. 2022 Dec 8;185 (25) :4801-4810.e13.|Cell. 2023 Nov 22;186 (24) :5363-5374.e16.|Cell. 2025 May 29;188 (11) :3013-3029.e19.|Ecotoxicol Environ Saf. 2021 Apr 1:212:111991.|Ecotoxicol Environ Saf. 2025 Nov 15:307:119433.|Patent. US20180263995A1.|SSRN. 2023 Nov 8.|Cell. 2025 May 29;188 (11) :3013-3029.e19.|Front Bioeng Biotechnol. 2022 Mar 17;10:826093.|Viruses. 2021 Jun 28;13 (7) :1255.

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