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24-Norursodeoxycholic acid

CAT: 0804-HY-101737-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101737-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
24-norursodeoxycholic acid (Norucholic acid) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.
CAS Number
99697-24-2
Product Name Alternative
Norucholic acid; nor-UDCA
UNSPSC
12352211
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/24-Norursodeoxycholic_acid.html
Purity
99.68
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@H](CC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C23H38O4
Molecular Weight
378.55
References & Citations
[1]Fickert P, et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology. 2006 Feb;130 (2) :465-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

Norucholic Acid

norUrsodeoxycholic acid is under investigation in clinical trial NCT03872921 (Norursodeoxycholic Acid vs Placebo in PSC).

CAS Number99697-24-2
PubChem CID192254
IUPAC Name(3R)-3-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]butanoic acid
Molecular FormulaC23H38O4
Molecular Weight378.5
XLogP4.6
Topological Polar Surface Area77.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity591
SMILES
C[C@H](CC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C
InChI
InChI=1S/C23H38O4/c1-13(10-20(26)27)16-4-5-17-21-18(7-9-23(16,17)3)22(2)8-6-15(24)11-14(22)12-19(21)25/h13-19,21,24-25H,4-12H2,1-3H3,(H,26,27)/t13-,14+,15-,16-,17+,18+,19+,21+,22+,23-/m1/s1
InChIKey
QYYDXDSPYPOWRO-JHMCBHKWSA-N
Chemical Structure
2D Structure
2D structure of Norucholic Acid
CAS: 99697-24-2
CID: 192254
Formula: C23H38O4
MW: 378.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight378.5
XLogP34.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass378.27700969
Monoisotopic Mass378.27700969
Topological Polar Surface Area77.8 Ų
Heavy Atom Count27
Formal Charge0
Complexity591
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS575260124-Norursodeoxycholic acid
A19546-20024-Norursodeoxycholic acid 200mg
A19546-5024-Norursodeoxycholic acid 50mg
A19546-1024-Norursodeoxycholic acid 10mg
A19546-124-Norursodeoxycholic acid 1mg
A19546-10024-Norursodeoxycholic acid 100mg
A19546-2524-Norursodeoxycholic acid 25mg
A19546-524-Norursodeoxycholic acid 5mg
A19546-10mM-D24-Norursodeoxycholic acid 10mM * 1mL in DMSO
RM-D221048-01Norursodeoxycholic Acid

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