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Omburtamab

CAT: 0804-HY-P99157-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99157-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Omburtamab is a humanized monoclonal antibody targeting B7-H3 (CD276) . Omburtamab selectively binds to B7-H3 highly expressed on the surface of tumor cells and activates anti-tumor immune responses mediated by T cells and natural killer (NK) cells. Omburtamab can promote the specific infiltration of CAR-T cells into tumors, enhance the killing function of NK cells through the CD16 signaling pathway, and regulate tumor cell glucose metabolism (such as inhibiting the Warburg effect) . Omburtamab has the potential to inhibit solid tumors such as non-small cell lung cancer (NSCLC) [1][2].
CAS Number
1895083-75-6
UNSPSC
12352203
Target
CD276/B7-H3
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/omburtamab.html
Purity
99.16
Solubility
10 mM in DMSO
Smiles
[Omburtamab]
Molecular Weight
(144.98 kDa)
References & Citations
[1]Liu J, et al. Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes. J Hematol Oncol. 2021 Jan 29;14 (1) :21.|[2]Kaplon H, et al. Antibodies to watch in 2020. MAbs. 2020 Jan-Dec;12 (1) :1703531.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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