2-MNG

• UNSPSC Description :

  2-MNG (2-Mercaptonicotinoyl glycine) is an inhibitor for melanogenesis with an average IC50 of 49.5μM in normal human melanocytes. 2-MNG binds to melanin precursors, prevents the incorporation into growing melanin, and thereby inhibits the synthesis of eumelanin and pheomelanin. 2-MNG can be used in research about skin pigmentation[1].

• Target Antigen :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/2-mng.html

• Solubility :

  DMSO : 116.67 mg/mL (ultrasonic)

• Smiles :

  O=C(O)CNC(C1=CC=CNC1=S)=O

• Molecular Weight :

  212.23

• References & Citations :

  [1]Sextius P, et al., 2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity. Pigment Cell Melanoma Res. 2024 Jul;37(4):462-479.

• Shipping Conditions :

  Room Temperature

• Clinical Information :

  No Development Reported

• CAS Number :

  [2101538-28-5]