Epiberberine (chloride)
CAT:
804-HY-N0226A-01
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Epiberberine (chloride)
- CAS Number: 889665-86-5
- UNSPSC Description: Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways[2]. Epiberberine has the potential effect in the research of diabetic disease[3].
- Target Antigen: Beta-secretase; Cholinesterase (ChE); Reactive Oxygen Species
- Type: Natural Products
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Metabolic Disease; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/Epiberberine-chloride.html
- Purity: 99.02
- Solubility: DMSO : 25 mg/mL (ultrasonic)
- Smiles: COC1=C(OC)C=C2C(CC[N+]3=C2C=C(C=C4)C(C5=C4OCO5)=C3)=C1.[Cl-]
- Molecular Weight: 371.81
- References & Citations: [1]Jung HA, et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32(8):1433-8.|[2]Choi JS, et al. Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Arch Pharm Res. 2015 Dec;38(12):2153-62.|[3]Ma H, et al. Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice. Drug Dev Res. 2016 Jun;77(4):163-70.Molecules. 2024 May 14.|Aging (Albany NY). 2021 Oct 9;13(19):23193-23209.|J Biomol Struct Dyn. 2022 Dec 29;1-38.|J Ethnopharmacol. 2024 Feb 19:117931.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported