AZD-7648
CAT:
804-HY-111783-07
Size:
250 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
AZD-7648
- CAS Number: 2230820-11-6
- UNSPSC Description: AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity[1].
- Target Antigen: Apoptosis; ATM/ATR; DNA-PK; PI3K
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;PI3K/Akt/mTOR
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/AZD-7648.html
- Purity: 99.86
- Solubility: DMSO : 5.83 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: CC1=CC2=NC=NN2C=C1NC3=NC=C(N(C)C(N4C5CCOCC5)=O)C4=N3
- Molecular Weight: 380.40
- References & Citations: [1]Fok JHL, et al. AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. Nat Commun. 2019 Nov 7;10(1):5065.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: Phase 2