SingleFlowEx MPO FITC

SingleFlowEx MPO FITC

• Description: SingleFlowEx is fluorochrome-labeled monoclonal antibody single reagent for use in laboratory-developed multicolor flow cytometry tests in order to examine human clinical samples. SingleFlowEx can be used in various multicolor combinations. Laboratory shall establish the SingleFlowEx performance characteristics in conjunction with other reagents in normal and pathological samples.
• Certification: RUO, GMP
• Clone: MPO421-8B2
• Validated Applications: FC
• Concentration: 0.100 mg/mL
• Format: FITC
• Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Components: 1 vial of monoclonal antibody reagent. The content (1 mL) is sufficient for min. 100 Tests.
• References & Citations: *Locke M, Francis RJ, Tsaousi E, Longstaff C: Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin. Sci Rep. 2020 Jul 1610(1):11694., URL: https://pubmed.ncbi.nlm.nih.gov/32678135/,*Use of this product has not been published., URL: ,
• Other References: *Ximenes VF, Maghzal GJ, Turner R, Kato Y, Winterbourn CC, Kettle AJ: Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione. Biochem J. 2009 Dec 14425(1):285-93., URL: https://www.ncbi.nlm.nih.gov/pubmed/19828014,*Hansson M, Olsson I, Nauseef WM: Biosynthesis, processing, and sorting of human myeloperoxidase. Arch Biochem Biophys. 2006 Jan 15445(2):214-24., URL: https://www.ncbi.nlm.nih.gov/pubmed/16183032,*Ximenes VF, Silva SO, Rodrigues MR, Catalani LH, Maghzal GJ, Kettle AJ, Campa A: Superoxide-dependent oxidation of melatonin by myeloperoxidase. J Biol Chem. 2005 Nov 18280(46):38160-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/16148002,*Chooklin S, Pereyaslov A, Bihalskyy I: Pathogenic role of myeloperoxidase in acute pancreatitis. Hepatobiliary Pancreat Dis Int. 2009 Dec8(6):627-31., URL: https://www.ncbi.nlm.nih.gov/pubmed/20007081,*Murphy EJ, Maréchal A, Segal AW, Rich PR: CO binding and ligand discrimination in human myeloperoxidase. Biochemistry. 2010 Mar 1649(10):2150-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/20146436,
• Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.