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Valencene

CAT: 0804-HY-N6636-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6636-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model[1][2][3].
CAS Number
4630-07-3
UNSPSC
12352211
Hazard Statement
H304
Target
Interleukin Related; NF-κB
Type
Natural Products
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/valencene.html
Concentration
10mM
Purity
81.81
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C=C([C@@H]1CCC2=CCC[C@@H](C)[C@]2(C)C1)C
Molecular Formula
C15H24
Molecular Weight
204.35
Precautions
H304
References & Citations
[1]Yang IJ, et al. Inhibitory Effect of Valencene on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. Evid Based Complement Alternat Med. 2016;2016:9370893.|[2]Frohwitter J, et al. Production of the sesquiterpene (+) -valencene by metabolically engineered Corynebacterium glutamicum. J Biotechnol. 2014 Dec 10;191:205-13.|[3]Marques FM, et al. In vitro anti-inflammatory activity of terpenes via suppression of superoxide and nitric oxide generation and the NF-κB signalling pathway. Inflammopharmacology. 2019 Apr;27 (2) :281-289.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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