Valencene

• Description :

  Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model[1][2][3].

• UNSPSC :

  12352211

• Hazard Statement :

  H304

• Target :

  Interleukin Related; NF-κB

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/valencene.html

• Concentration :

  10mM

• Purity :

  81.81

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  C=C([C@@H]1CCC2=CCC[C@@H](C)[C@]2(C)C1)C

• Molecular Formula :

  C15H24

• Molecular Weight :

  204.35

• Precautions :

  H304

• References & Citations :

  [1]Yang IJ, et al. Inhibitory Effect of Valencene on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. Evid Based Complement Alternat Med. 2016;2016:9370893.|[2]Frohwitter J, et al. Production of the sesquiterpene (+) -valencene by metabolically engineered Corynebacterium glutamicum. J Biotechnol. 2014 Dec 10;191:205-13.|[3]Marques FM, et al. In vitro anti-inflammatory activity of terpenes via suppression of superoxide and nitric oxide generation and the NF-κB signalling pathway. Inflammopharmacology. 2019 Apr;27 (2) :281-289.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [4630-07-3]