Centhaquin

• Description :

  Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models[1][2].

• CAS Number :

  [57961-90-7]

• Product Name Alternative :

  Centhaquine; PMZ-2010

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H413

• Target :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/centhaquin.html

• Purity :

  99.93

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  CC1=CC=CC(N(CC2)CCN2CCC3=NC4=C(C=CC=C4)C=C3)=C1

• Molecular Formula :

  C22H25N3

• Molecular Weight :

  331.45

• Precautions :

  H315, H319, H413

• References & Citations :

  [1]Srimal RC, et al. Pharmacological studies on 2- (2- (4- (3-methylphenyl) -1-piperazinyl) ethyl) quinoline (centhaquin) . I. Hypotensive activity.Pharmacol Res. 1990 May-Jun;22 (3) :319-29.|[2]Papalexopoulou K, et al. Centhaquin Effects in a Swine Model of Ventricular Fibrillation: Centhaquin and Cardiac Arrest.Heart Lung Circ. 2017 Aug;26 (8) :856-863.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 4