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ICCB280

CAT: 0804-HY-134333-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134333-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc) [1][2].
CAS Number
2041072-41-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iccb280.html
Purity
98.14
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4
Molecular Formula
C23H18N2O4
Molecular Weight
386.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Radomska HS, et, al. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen. 2015 Oct;20 (9) :1150-9.|[2]Sridhar R, et, al. Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα. Molecules. 2018 Aug 3;23 (8) :1938.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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