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Alogabat

CAT: 0804-HY-132806-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132806-01Size:5 mg
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Description
Alogabat is a positive allosteric modulator (PAM) and agonist (Ki GABAA α5 receptor, targeting the α5β3γ2 subunit with a Ki of 8.7 nM. Alogabat increases the expression level of α5β3γ2 in oocytes (1.97-fold) . GABAA has been implicated in cognitive impairment associated with central nervous system (CNS) disorders, brain cancer (including brain tumors such as medulloblastoma), and can be used in the study of mild cognitive impairment (MCI), amnestic MCI (aMCI), age-associated memory impairment (AAMI), age-related cognitive decline (ARCD), dementia, Alzheimer's disease (AD), prodromal AD, post-traumatic stress disorder (PTSD), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis (ALS), cognitive impairment associated with cancer treatment, mental retardation, Parkinson's disease (PD), autism spectrum disorder, fragile X, Rett syndrome, obsessive-compulsive behavior, and substance addiction[1][2].
CAS Number
2230009-48-8
Product Name Alternative
RG-7816; RO-7017773
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/alogabat.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(C1=NN=C(OCC2=C(C)ON=C2C3=CC=C(C)N=C3)C=C1)NC4CCOCC4
Molecular Formula
C21H23N5O4
Molecular Weight
409.44
References & Citations
[1]Bernd Buettelmann, et al. Preparation of new isoxazolyl ether derivatives as GABAA α5 receptor positive allosteric modulators (PAMs) . World Intellectual Property Organization, WO2018104419 A1 2018-06-14.|[2]Belew Mekonnen, et al. Benzazepine derivatives for the treatment of cognitive impairment and their preparation. World Intellectual Property Organization, WO2024039886 A1 2024-02-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
BA6674-5.1Alogabat

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