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ITF5924

CAT: 0804-HY-161306Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161306Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ITF5924 (compound 1) is a potent and highly selective HDAC6 inhibitor with an IC50 of 7.7 nM. ITF5924 shows greater than 104-fold selectivity for HDAC6 over all other HDAC subtypes. ITF5924 containing a difluoromethyl-1,3,4-oxadiazole (DFMO) moiety is slow-binding substrate analog of HDAC6 that undergo an enzyme-catalyzed ring opening reaction, forming a tight and long-lived enzyme-inhibitor complex[1].
CAS Number
2760854-72-4
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/itf5924.html
Solubility
10 mM in DMSO
Smiles
FC(F)C(O1)=NN=C1C(C=C2)=CC=C2CN3N=NC(C4=CC=C(NC5=NCCN5)C=C4)=C3
Molecular Formula
C21H18F2N8O
Molecular Weight
436.42
References & Citations
[1]Edoardo Cellupica, et al. Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity. J Biol Chem. 2023 Jan;299 (1) :102800.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6

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CatalogName
T86748-01ITF5924

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