Cytidine-5′-triphosphate-d14 (disodium)

Cytidine-5′-triphosphate-d14 (disodium)

• UNSPSC Description: Cytidine-5′-triphosphate-d14 (disodium) is the deuterium labeled Cytidine-5'-triphosphate[1]. Cytidine 5′-triphosphate (Cytidine triphosphate;5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii[2].
• Target Antigen: DNA/RNA Synthesis; Endogenous Metabolite; Nucleoside Antimetabolite/Analog
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Field of Research: Cancer
• Purity: 98.00
• Solubility: 10 mM in DMSO
• Smiles: O=P(O[2H])(O[Na])OP(OP(OC([2H])([2H])[C@@]1([2H])[C@](O[2H])([2H])[C@@](O[2H])([2H])[C@](N2C(N=C(N([2H])[2H])C([2H])=C2[2H])=O)([2H])O1)(O[2H])=O)(O[Na])=O
• Molecular Weight: 541.21
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Heidy Y Narvaez-Ortiz, et al. A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii. Front Cell Infect Microbiol. 2018 Mar 22;8:83.
• Shipping Conditions: Blue Ice
• Storage Conditions: Solution, -20°C, protect from light, 2 years
• Clinical Information: No Development Reported