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Unesbulin

CAT: 0804-HY-112041-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112041-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity[1][2].
CAS Number
1610964-64-1
Product Name Alternative
PTC596
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; BMI1
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ptc596.html
Purity
99.17
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
NC1=C(F)C(NC2=CC=C(C(F)(F)F)C=C2)=NC(N3C4=CC(F)=CC=C4N=C3C)=N1
Molecular Formula
C19H13F5N6
Molecular Weight
420.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Nishida Y, et al. The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood Cancer J. 2017 Feb 17;7 (2) :e527.|[2]BMI1 inhibitor PTC596
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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