Go 6983

CAT: 0804-HY-13689-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13689-01Size:5 mg
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Description
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
CAS Number
[133053-19-7]
Product Name Alternative
Gö 6983; Goe 6983
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Go-6983.html
Concentration
10mM
Purity
99.23
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C(C1=CN(CCCN(C)C)C2=C1C=C(OC)C=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O
Molecular Formula
C26H26N4O3
Molecular Weight
442.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Gschwendt M, et al. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett, 1996, 392 (2), 77-80.|[2]Peterman EE, et al. G0 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol, 2004, 43 (5), 645-656.|[3]Young LH, et al. G0 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev, 2005, 23 (3), 255-272.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCα; PKCβ; PKCγ; PKCδ; PKCζ; PKCμ

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