Recombinant Human IL2 Protein, mFc Tag

CAT: 0793-32-17639-100Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0793-32-17639-100Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Molecular Characterization: IL2 (Ala21-Thr153) mFc (Pro99-Lys330) Molecular weight: The protein has a predicted molecular mass of 41.5 kDa after removal of the signal peptide.The apparent molecular mass of IL2-mFc is approximately 35-55 kDa due to glycosylation.Description: Recombinant Human IL2 with C-terminal mouse Fc tagThis gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4 and CD8 T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Product Name Alternative

IL-2, lymphokine, TCGF

UniProt

P60568

Host

HEK293

Target Antigen

IL2

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.

UniProtKB · P60568

Interleukin-2

IL2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P60568
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: IL2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: IL-2
EC number: —
Processing: Precursor
Secondary accessions: P01585

Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Chromosomal rearrangement

Molecular function

CytokineGrowth factor

PTM

Disulfide bondGlycoprotein

Disease

Proto-oncogene

Cellular component

Secreted

Domain

Signal

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