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Recombinant Human CD38 Protein, hFc Tag

CAT: 0793-32-17606-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0793-32-17606-100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Molecular Characterization: CD38 (Val43-Ile300) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 56.0 kDa after removal of the signal peptide.The apparent molecular mass of CD38-hFc is approximately 70-100 kDa due to glycosylation.Description: Recombinant human CD38 protein with C-terminal human Fc tagCD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2 . The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
Product Name Alternative
CD38, T10, cADPr hydrolase 1
UniProt
P28907
Host
HEK293
Target Antigen
CD38
Components
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.
Storage Conditions
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.

UniProtKB · P28907

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

CD38_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P28907
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD38
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.2.2.-, 3.2.2.6
Processing
—
Secondary accessions
O00121, O00122, Q96HY4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

Disease

Diabetes mellitus

PTM

Disulfide bondGlycoprotein

Molecular function

HydrolaseReceptorTransferase

Ligand

NADNADP

Domain

Signal-anchorTransmembraneTransmembrane helix

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